Anticoagulation Comparison Chart: A Quick Guide for Prescribers
This chart is for general informational purposes and notes FDA-approved indications for oral antiplatelet
medications only. The information presented here does not capture all clinical scenarios in which antiplatelet
therapy may be used. For specific questions, please contact your pharmacy team.
Brand
Brand
JANTOVEN®
JANTOVEN®
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Apixaban tablets
Apixaban tablets
Apixaban tablets
Rivaroxaban
Rivaroxaban
Rivaroxaban
Dabigatran
Dabigatran
Dabigatran
Edoxaban
Edoxaban
Edoxaban
Generic
Generic
Generic
Indications Approved by the United States Food and Drug Administration (FDA)
Indications Approved by the United States Food and Drug Administration (FDA)
Stroke Prevention in Atrial Fibrillation (AF)
Stroke Prevention in Atrial Fibrillation (AF)
AF with mechanical valves or mitral valve stenosis
AF with mechanical valves or mitral valve stenosis
AF with mechanical valves or mitral valve stenosis
AF without mechanical valves or mitral valve stenosis
AF without mechanical valves or mitral valve stenosis
AF without mechanical valves or mitral valve stenosis
Venous Thromboembolism (VTE)
Venous Thromboembolism (VTE)
Treatment of VTE
Treatment of VTE
Treatment of VTE
Secondary prevention in patients already treated for VTE
Secondary prevention in patients already treated for VTE
Secondary prevention in patients already treated for VTE
Prophylaxis after hip replacement surgery
Prophylaxis after hip replacement surgery
Prophylaxis after hip replacement surgery
Prophylaxis after knee replacement surgery
Prophylaxis after knee replacement surgery
Prophylaxis after knee replacement surgery
Prophylaxis in the hospital and after discharge in adults with acute medical illness
Prophylaxis in the hospital and after discharge in adults with acute medical illness
Prophylaxis in the hospital and after discharge in adults with acute medical illness
Prophylaxis of major cardiovascular events in patients with CAD and/or PAD – and in combination with aspirin
Prophylaxis of major cardiovascular events in patients with CAD and/or PAD – and in combination with aspirin
Prophylaxis of major cardiovascular events in patients with CAD and/or PAD – and in combination with aspirin
Boxes marked with a green dot indicate well-established uses of warfarin that do not appear in the drug's package insert. Warfarin is also commonly used in antiphospholipid syndrome (APS). Please consult your pharmacy team for specific questions about warfarin use.
Boxes marked with a green dot indicate well-established uses of warfarin that do not appear in the drug's package insert. Warfarin is also commonly used in antiphospholipid syndrome (APS). Please consult your pharmacy team for specific questions about warfarin use.
Boxes marked with a green dot indicate well-established uses of warfarin that do not appear in the drug's package insert. Warfarin is also commonly used in antiphospholipid syndrome (APS). Please consult your pharmacy team for specific questions about warfarin use.
Acute medical illness: Conditions such as pneumonia, stroke, heart failure, infection, or inflammatory disease
Acute medical illness: Conditions such as pneumonia, stroke, heart failure, infection, or inflammatory disease
Acute medical illness: Conditions such as pneumonia, stroke, heart failure, infection, or inflammatory disease
CAD: Coronary artery disease
Major cardiovascular (CV) events: CV death, heart attack, and stroke
CAD: Coronary artery disease
Major cardiovascular (CV) events: CV death, heart attack, and stroke
CAD: Coronary artery disease
Major cardiovascular (CV) events: CV death, heart attack, and stroke
PAD: Peripheral artery disease
PAD: Peripheral artery disease
PAD: Peripheral artery disease
Brand
Brand
JANTOVEN®
JANTOVEN®
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Apixaban tablets
Apixaban tablets
Apixaban tablets
Rivaroxaban
Rivaroxaban
Rivaroxaban
Dabigatran
Dabigatran
Dabigatran
Edoxaban
Edoxaban
Edoxaban
Drug Image and Available Dosages (The front and back of each tablet is shown in these pictures.)
Drug Image and Available Dosages (The front and back of each tablet is shown in these pictures.)
Drug Image and Available Dosages (The front and back of each tablet is shown in these pictures.)
Tablet
Tablet
Colors & shapes vary by dose
Colors & shapes vary by dose
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Onset
Onset
Onset
Days
Days
Hours
Hours
Hours
Hours
Hours
Hours
Hours
Hours
Renal Dose Adjustment
Renal Dose Adjustment
Renal Dose Adjustment
No
No
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Food Efects
Food Efects
Food Efects
Yes
Yes
Vitamin K Interactions
Vitamin K Interactions
No
No
Yes
Yes
Must take 15-mg and 20-mg doses with food
Must take 15-mg and 20-mg doses with food
No
No
No
No
Drug Interactions
Drug Interactions
Drug Interactions
Many
Many
Few
Few
Few
Few
Few
Few
Few
Few
Routine Drug Monitoring
Routine
Drug
Monitoring
Routine
Drug
Monitoring
Yes
Yes
Not Needed
Not Needed
Complete blood count and kidney/liver function tests recommended annually (more frequently in some patients)
Complete blood count and kidney/liver function tests recommended annually (more frequently in some patients)
Reversal Agents
Reversal Agents
Reversal Agents
If FDA-approved agents aren’t available, 4-factor prothrombin complex concentrate (4F-PCC; brand name KCentra®) is an alternative for all agents.
If FDA-approved agents aren’t available, 4-factor prothrombin complex concentrate (4F-PCC; brand name KCentra®) is an alternative for all agents.
If FDA-approved agents aren’t available, 4-factor prothrombin complex concentrate (4F-PCC; brand name KCentra®) is an alternative for all agents.
Yes
Yes
4F-PCC Vitamin K, fresh frozen plasma
4F-PCC Vitamin K, fresh frozen plasma
Yes
Yes
Andexxa® (andexanet alfa)
Andexxa® (andexanet alfa)
Yes
Yes
Andexxa® (andexanet alfa)
Andexxa® (andexanet alfa)
Yes
Yes
Praxbind® (idarucizumab)
Praxbind® (idarucizumab)
Not Yet
Not Yet
No FDA-approved reversal agents currently
No FDA-approved reversal agents currently