Host Dr. Alex Spyropoulos is joined by global experts Drs. James Douketis and Marc Samama for a focused, practical discussion on perioperative anticoagulation management in nonurgent procedures. Together, they clarify:

• When and how to safely interrupt warfarin and direct oral anticoagulants

• Why heparin bridging is now rarely needed

• How procedural bleeding risk and pharmacokinetics inform decision-making

The episode reviews evidence from key clinical trials, outlines when anticoagulation can safely be continued for minimal-bleed-risk procedures, and explores future directions—including the potential role of Factor XI inhibitors in the perioperative setting.

Don’t miss this concise, guideline-driven conversation for clinicians managing anticoagulated patients or working within perioperative care teams.

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