Anticoagulation Comparison Chart: A Quick Guide for Patients
Your healthcare provider may prescribe an anticoagulant (sometimes called a blood thinner) after you have a blood clot. There are several anticoagulants on the market and navigating your options can be overwhelming.
VLN has designed a reference chart that compares all available anticoagulants, including warfarin and the direct oral anticoagulants (DOACs).
This is a great tool to review with your doctor or healthcare provider when discussing your medication options.
This chart is for general informational purposes and notes FDA-approved indications for oral antiplatelet
medications only. The information presented here does not capture all clinical scenarios in which antiplatelet
therapy may be used. For specific questions, please contact your pharmacy team.
Brand
Brand
JANTOVEN®
JANTOVEN®
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Apixaban tablets
Apixaban tablets
Apixaban tablets
Rivaroxaban
Rivaroxaban
Rivaroxaban
Dabigatran
Dabigatran
Dabigatran
Edoxaban
Edoxaban
Edoxaban
Generic
Generic
Generic
WHAT ARE THESE MEDICATIONS APPROVED FOR?
WHAT ARE THESE MEDICATIONS APPROVED FOR?
Preventing Stroke in Atrial Fibrillation (Afib)
Preventing Stroke in Atrial Fibrillation (Afib)
AF without mechanical valves or mitral valve stenosis
AF without mechanical valves or mitral valve stenosis
AF without mechanical valves or mitral valve stenosis
AF with mechanical valves or mitral valve stenosis
AF with mechanical valves or mitral valve stenosis
AF with mechanical valves or mitral valve stenosis
Prevent and Treating Blood Clots in the Veins, aka Venous Thromboembolism (VTE)
Prevent and Treating Blood Clots in the Veins, aka Venous Thromboembolism (VTE)
Treatment of blood clots
Treatment of blood clots
Treatment of blood clots
Preventing future blood clots in patients already treated for a clot
Preventing future blood clots in patients already treated for a clot
Preventing future blood clots in patients already treated for a clot
Preventing blood clots after hip replacement surgery
Preventing blood clots after hip replacement surgery
Preventing blood clots after hip replacement surgery
Preventing blood clots after knee replacement surgery
Preventing blood clots after knee replacement surgery
Preventing blood clots after knee replacement surgery
Preventing major cardiovascular events in patients with CAD and/or PAD - and in combination with aspirin
Preventing major cardiovascular events in patients with CAD and/or PAD - and in combination with aspirin
Preventing major cardiovascular events in patients with CAD and/or PAD - and in combination with aspirin
Boxes marked with a green dot indicate well-established uses of warfarin that do not appear in the drug's package insert. Warfarin is also commonly used in antiphospholipid syndrome (APS). Please consult your pharmacy team for specific questions about warfarin use.
Boxes marked with a green dot indicate well-established uses of warfarin that do not appear in the drug's package insert. Warfarin is also commonly used in antiphospholipid syndrome (APS). Please consult your pharmacy team for specific questions about warfarin use.
Boxes marked with a green dot indicate well-established uses of warfarin that do not appear in the drug's package insert. Warfarin is also commonly used in antiphospholipid syndrome (APS). Please consult your pharmacy team for specific questions about warfarin use.
Afib: An irregular heartbeat that can raise your risk for a stroke. A mechanical heart valve is used to replace a damaged valve and to help control blood flow to and from the hear.
CAD: Coronary artery disease
Major cardiovascular (CV) events: CV death, heart attack, and stroke
CAD: Coronary artery disease
Major cardiovascular (CV) events: CV death, heart attack, and stroke
CAD: Coronary artery disease
Major cardiovascular (CV) events: CV death, heart attack, and stroke
PAD: Peripheral artery disease
VTE: Venous thromboembolism refers to blood clots in the veins of the legs, thighs, arms, or elsewhere in the body.
PAD: Peripheral artery disease
VTE: Venous thromboembolism refers to blood clots in the veins of the legs, thighs, arms, or elsewhere in the body.
PAD: Peripheral artery disease
VTE: Venous thromboembolism refers to blood clots in the veins of the legs, thighs, arms, or elsewhere in the body.
Brand
Brand
JANTOVEN®
JANTOVEN®
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Warfarin*
Coumadin® was discontinued in April 2020
Apixaban tablets
Apixaban tablets
Apixaban tablets
Rivaroxaban
Rivaroxaban
Rivaroxaban
Dabigatran
Dabigatran
Dabigatran
Edoxaban
Edoxaban
Edoxaban
Drug Image and Available Dosages (The front and back of each tablet is shown in these pictures.)
Drug Image and Available Dosages (The front and back of each tablet is shown in these pictures.)
Drug Image and Available Dosages (The front and back of each tablet is shown in these pictures.)
Tablet
Tablet
Colors & shapes vary by dose
Colors & shapes vary by dose
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Onset
How long does it take for the drug to work?
Onset
How long does it take for the drug to work?
Onset
How long does it take for the drug to work?
Days
Days
Hours
Hours
Hours
Hours
Hours
Hours
Hours
Hours
Kidney Function
Does my kidney function affect how this drug works?
Kidney Function
Does my kidney function affect how this drug works?
Kidney Function
Does my kidney function affect how this drug works?
No
No
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Food Effects
Does food affect how this drug works?
Food Effects
Does food affect how this drug works?
Food Effects
Does food affect how this drug works?
Yes
Yes
Vitamin K Interactions
Vitamin K Interactions
No
No
Yes
Yes
Must take 15-mg and 20-mg doses with food
Must take 15-mg and 20-mg doses with food
No
No
No
No
Drug Interactions
How many other drugs interact with this drug?
Drug Interactions
How many other drugs interact with this drug?
Drug Interactions
How many other drugs interact with this drug?
Many
Many
Few
Few
Few
Few
Few
Few
Few
Few
Routine Drug Monitoring
Routine
Drug
Monitoring
Routine
Drug
Monitoring
Yes
Yes
Not Needed
Not Needed
Complete blood count and kidney/liver function tests recommended annually (more frequently in some patients)
Complete blood count and kidney/liver function tests recommended annually (more frequently in some patients)