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What’s Hot in Clots – September 2024
Key Updates in Thrombosis
Table of Contents
There is a lot to discuss from ESC, including ASSURE-DES, OCEANIC-AF, EPIC-CAD and others that will be part of my coverage next month. For now, here are my picks for this month:
Antithrombotic therapy after left atrial appendage occlusion (LAAO)
LAAO is performed commonly with the goal of de-escalating antithrombotic therapy. However, early after successful procedures, it’s unclear what constitutes the best antithrombotic therapy regimen to balance bleeding versus thrombotic events. This interesting trial, albeit small, compared low-intensity apixaban with clopidogrel-based DAPT, and suggested superior results with apixaban for a composite outcome that included bleeding and ischemic events. Read more.
Perioperative management of DOACs
In my mind, there is a spectrum of review papers; I see review papers that are less helpful, good review papers, excellent papers, and then classics, i.e., ones that I may want to print or keep somewhere easily accessible on my computer to use frequently, as needed. This paper on perioperative DOAC management is definitely from the last category! The figures are just terrific and provide a great summary for the readers as well. Read more.
Superficial vein thrombosis: What are the options for anticoagulation?
This systematic review and meta-analysis looked into randomized trials of different anticoagulant regimens for management of superficial vein thrombosis. I wouldn’t read too much into comparisons in the network due to differences in trial design and duration of treatment, but still – an informative study. Read more.
Anticoagulation regimens in patients undergoing interventions for pulmonary embolism (PE)
A lot has been said and a lot is being done (RCTs and registries) with respect to interventions⏤surgical or endovascular⏤should be considered for sicker patients with PE. What is typically left out is how to use anticoagulation in these patients. We need RCTs! But in the interim, here’s a summary from the existing studies. Read more.
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Behnood Bikdeli, MD, MS
Cardiologist, Section of Vascular Medicine, Division of Cardiovascular Medicine, Brigham and Women’s Hospital
Investigator, Thrombosis Research Group, Division of Cardiovascular Medicine, Brigham and Women’s Hospital
Assistant Professor of Medicine, Harvard Medical School
Investigator, Yale/ YNHH Center for Outcomes Research and Evaluation, Yale School of Medicine
Investigator, Cardiovascular Research Foundation
